The objectives of this grant have been to: 1. Provide the best possible physical environment for the research animals. 2. Provide an animal operating room conducive to sterile survival surgical procedures and equipped with adequate instruments and supplies. 3. Provide a modern, versatile animal caging system. 4. Provide technicl support for activities that are needed but heretofore unfunded. We accomplished the first three objectives during the 01 year. During the 02 and 03 year we will be accomplishing the forth objective and will be developing plans for the perpetuation of those positions.